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KMID : 0616120170480010038
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Korean Journal of Pharmacognosy
2017 Volume.48 No. 1 p.38 ~ p.45
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Inhibitory Effects of Black-red Ginseng Extracts on Allergic Inflammation In Vitro and In Vivo
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Yeom Mi-Jung
Oh Ju-Young
Lee Bom-Bi
Hahm Dae-Hyun
Park Hi-Joon
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Abstract
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Black-red ginseng (BRGP) exhibits more potent biological activities than white and red ginseng. However, the effect of BRGP on allergic inflammation has not been studied extensively. In this study, we attempted to evaluate the effects of BRGP on allergic inflammation in vitro and in vivo. The effects of BRGP on pro-inflammatory mediators in phorbol myristate acetate (PMA) and A23187-stimulated human mast cells (HMC-1) and on trimellitic anhydride (TMA)-induced atopic dermatitis-like skin lesions in BALB/c mice were evaluated. BRGP suppressed the expression of TNF-α, IL-6 and IL-8 from HMC-1 stimulated with PMA and A23187. Furthermore, the oral administration of BRGP markedly significantly reduced apparent severity of atopic dermatitis-like skin lesions, ear swelling, lymph node weight gains and serum IgE levels induced by TMA in mice. BRGP treatment also ameliorated epidermal hyperplasia and infiltration of inflammatory cells including mast cells. Taken together, BRGP possesses significant anti-atopic efficacy, suggesting that it could be used as a potential therapeutic agent for allergic inflammatory diseases, including atopic dermatitis.
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KEYWORD
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Black-red ginseng, Allergic inflammation, Atopic dermatitis, Mast cells, Pro-inflammatory cytokines
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